name: Оптические и фотофизические свойства биосовместимых гибридных структур на основе тетрапиррольных соединений и квантовых точек, пассивированных хитозаном
keyword_list: Hybrid structures; quantum dots; singlet oxygen; tetraphenylporphyrin; chlorin e6; chitosan
abstract: Today, hybrid structures based on semiconductor quantum dots and tetrapyrrole molecules are the subject of intense experimental research in the field of low-dimensional systems physics. Interest in hybrid structures is due, on the one hand, to the desire to establish the physical mechanisms of interaction between nanocrystals and tetrapyrrole molecules. On the other hand, hybrid structures have wide potential practical applications in photonics, optoelectronics, chemistry, biology, and medicine. Hybrid structures based on semiconductor quantum nanocrystals, in particular quantum dots, and molecules capable of generating reactive oxygen species are promising materials that can replace traditional drugs used today for photodynamic diagnosis and therapy of oncological diseases and many bacterial infections. To date, many works investigate hybrid structures based
  on nanocrystals of various shapes and tetrapyrrole compounds that can selectively accumulate in tumor tissues and generate reactive oxygen species, including singlet oxygen. The scientific qualification work is devoted to establishing the patterns of formation and photophysical processes occurring in hybrid structures based on semiconductor quantum dots and tetrapyrrole molecules. The aim of the thesis is to establish the regularities of the photophysical properties of tetraphenylporphyrin in hybrid structures with quantum dots and the regularities of the electronic excitation relaxation in the structures.
  To achieve this goal, it was necessary to solve the following tasks:
  1. Form a model system based on CdSe/ZnS quantum dots and chlorin e6 in organic solvents and study its optical and photophysical properties.
  2. Form hybrid structures based on tetraphenylporphyrin (TPP) in a model medium and study their photophysical properties.
  3. Form hybrid structures based on water-soluble quantum dots and hydrophobic TPP molecules in a chitosan aqueous solution and study their photophysical properties.
  4. Study the optical and photophysical properties of CdSe/ZnS and AIS/ZnS quantum dots with TPP molecules in a chitosan aqueous solution and nanoparticles based on chitosan.
  5. Establish patterns of nonradiative energy transfer in the hybrid structures.
  6. Establish patterns of singlet oxygen generation in the presence of the hybrid structures.
  Scientific results. For the first time:
  1. The formation and study of the optical and photophysical properties of a set of hybrid structures based on semiconductor quantum dots and tetrapyrrole molecules have been performed. In the created set of hybrid structures, their components were successively varied from the classical II-VI CdSe/ZnS quantum dots and the classical chlorin e6 photosensitizer in organic solutions to new biocompatible structures based on I-III-VI Ag-In-S2/ZnS ternary quantum dots and hydrophobic tetraphenylporphyrin molecules. This approach has made it possible to reveal regularities in the efficiency of photoexcitation energy transfer and the generation of singlet oxygen in hybrid structures of this type.
  2. It is shown that magnetic circular dichroism spectroscopy helps confirm the interaction of the tetrapyrrole monomer with quantum dots in hybrid structures and at the same time can be used as an effective tool for revealing
  aggregates of the tetrapyrrole component in hybrid structures with quantum dots.
  3. A new approach to estimate the FRET efficiency based on the analysis of the concentration of singlet oxygen generated in the hybrid structures has been proposed.
  4. It has been shown that a comparison of FRET efficiency evaluations based on the analysis of (i) the sensitized luminescence of the acceptor, i.e., a monomer of a tetrapyrrole molecule, and (ii) singlet oxygen concentration
  makes it possible to determine the ratio of the rate of intersystem crossing S1- T1 of a tetrapyrrole molecule monomer of interacting with quantum dots and the free monomer.
  5. It has been shown that the use of chitosan as a matrix for TPP molecules makes it possible to partially preserve hydrophobic TPP molecules in the monomeric form in aqueous solutions. The TPP monomer embedded in
  chitosan has the same photophysical properties, i.e., PL quantum yield and singlet oxygen generation quantum yield, as the TPP monomer in an organic solvent and can be used as an efficient energy acceptor in biocompatible
  hybrid structures with quantum dots.
chairman_dissertation_council.name: Николай
chairman_dissertation_council.surname: Никоноров
chairman_dissertation_council.patronymic: Валентинович
chairman_dissertation_council.position: профессор (квалификационная категория "ведущий профессор"), факультет фотоники
chairman_dissertation_council.degree: Доктор физико-математических наук
chairman_dissertation_council.rank: Профессор
chairman_dissertation_council.wos_research_id: 0
chairman_dissertation_council.scopus_author_id: 7003772604
chairman_dissertation_council.territory: РОССИЯ
organization_supervisor.name: Владимир
organization_supervisor.surname: Васильев
organization_supervisor.patronymic: Николаевич
organization_supervisor.position: ректор
organization_supervisor.territory: РОССИЯ
rubrics.code: 34.17.43
rubrics.name: Биофизика тканей
rubrics.code: 29.19.22
rubrics.name: Физика наноструктур. Низкоразмерные структуры. Мезоскопические структуры
oecds.code: 01.06.DA
oecds.name: BIOPHYSICS
oecds.code: 01.04.EI
oecds.name: CHEMISTRY, PHYSICAL
oecds.code: 01.03.UB
oecds.name: PHYSICS, APPLIED
oecds.code: 01.03.SY
oecds.name: OPTICS
oecds.code: 01.01.UR
oecds.name: PHYSICS, MATHEMATICAL
speciality_codes.name: Оптика
speciality_codes.code: 1.3.6.
supervisors.fio: Орлова Анна Олеговна
supervisors.scientific_degree: Доктор физико-математических наук
supervisors.speciality_code: Оптика
supervisors.responsible_type: Научный руководитель
opponents.fio: Перова Татьяна Сергеевна
opponents.scientific_degree: Кандидат физико-математических наук
opponents.speciality_code: Оптика
opponents.responsible_type: Оппонент
opponents.fio: Рябчук Владимир Константинович
opponents.scientific_degree: Доктор физико-математических наук
opponents.speciality_code: Физика конденсированного состояния
opponents.responsible_type: Оппонент
protection_organization.short_name: УНИВЕРСИТЕТ ИТМО; НИУ ИТМО; ИТМО
protection_organization.name: ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ АВТОНОМНОЕ ОБРАЗОВАТЕЛЬНОЕ УЧРЕЖДЕНИЕ ВЫСШЕГО ОБРАЗОВАНИЯ "НАЦИОНАЛЬНЫЙ ИССЛЕДОВАТЕЛЬСКИЙ УНИВЕРСИТЕТ ИТМО"
protection_organization.ogrn: 1027806868154
protection_organization.supervisor_name: ВЛАДИМИР
protection_organization.supervisor_surname: ВАСИЛЬЕВ
protection_organization.supervisor_patronymic: НИКОЛАЕВИЧ
protection_organization.organization_type: Организация
protection_organization.okogu: Министерство науки и высшего образования Российской Федерации
protection_organization.okopf: Федеральные государственные автономные учреждения
author_organization.short_name: УНИВЕРСИТЕТ ИТМО; НИУ ИТМО; ИТМО
author_organization.name: ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ АВТОНОМНОЕ ОБРАЗОВАТЕЛЬНОЕ УЧРЕЖДЕНИЕ ВЫСШЕГО ОБРАЗОВАНИЯ "НАЦИОНАЛЬНЫЙ ИССЛЕДОВАТЕЛЬСКИЙ УНИВЕРСИТЕТ ИТМО"
author_organization.ogrn: 1027806868154
author_organization.supervisor_name: ВЛАДИМИР
author_organization.supervisor_surname: ВАСИЛЬЕВ
author_organization.supervisor_patronymic: НИКОЛАЕВИЧ
author_organization.organization_type: Организация
author_organization.okogu: Министерство науки и высшего образования Российской Федерации
author_organization.okopf: Федеральные государственные автономные учреждения